Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clear cell sarcoma: an institutional review.

Ira A Jacobs1, C K Chang, Grace Guzman

  • 1Department of Surgical Oncology, The University of Illinois at Chicago, Chicago, Illinois, USA.

The American Surgeon
|April 22, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional Outcomes and Quality of Life for Patients With Cachexia and Solid Tumour Cancers: Findings of a Systematic Literature Review.

Journal of cachexia, sarcopenia and muscle·2026
Same author

Long-read sequencing for cancer liquid biopsy: advancing precision oncology.

Frontiers in oncology·2026
Same author

Bereaved Caregiver Perspectives on Quality of Care at the End of Life Among Adolescents and Young Adults with Cancer.

Journal of palliative medicine·2026
Same author

Contributing Factors to Delay of Adjuvant Postsurgical Radiation for Malignant Brain Tumors: A Single Institution Experience in a Rural State.

American journal of clinical oncology·2025
Same author

Intestinal Epithelial Cell-derived Osteopontin Protects Against Metabolic Dysfunction-associated Steatohepatitis by Modulating Bile Acid Composition and the Gut Microbiome.

Cellular and molecular gastroenterology and hepatology·2025
Same author

Hepatic HKDC1 deletion alleviates western diet-induced MASH in mice.

Biochimica et biophysica acta. Molecular basis of disease·2025
Same journal

Complete Response of Merkel Cell Carcinoma to Immunotherapy and Single-Fraction Radiotherapy Following Severe COVID-19 Infection: A Case Report and Review of Immune Mechanism.

The American surgeon·2026
Same journal

Perioperative Acute Myocardial Infarction in Non-Cardiac Operations: A National Analysis.

The American surgeon·2026
Same journal

Outcomes of Completion Cholecystectomy: Association With Patient Comorbidity in a National Database.

The American surgeon·2026
Same journal

Building the Conversation: Editorial Stewardship in Contemporary Surgical Publishing.

The American surgeon·2026
Same journal

Musculoskeletal Pain in Surgeons on Operating Days.

The American surgeon·2026
Same journal

Splenectomy During Cytoreductive Surgery: Marker of Surgical Burden or Independent Predictor of Morbidity?

The American surgeon·2026
See all related articles

Clear cell sarcoma of the tendons and aponeuroses (CCSTA) is an aggressive soft-tissue tumor. Despite aggressive management, CCSTA has a high risk of distant metastasis, impacting patient survival.

Area of Science:

  • Oncology
  • Orthopedic Oncology
  • Soft Tissue Pathology

Background:

  • Clear cell sarcoma of the tendons and aponeuroses (CCSTA) is a rare, aggressive soft-tissue tumor.
  • CCSTA accounts for approximately 1% of all soft tissue sarcomas.
  • While potentially related to melanoma, CCSTA exhibits sarcoma-like behavior with a tendency for lymph node metastasis.

Purpose of the Study:

  • To report the clinical experience with CCSTA at a tertiary referral center.
  • To analyze patient data including tumor characteristics, recurrence patterns, and survival outcomes.
  • To evaluate the impact of treatment on CCSTA prognosis.

Main Methods:

  • Retrospective review of eight CCSTA cases diagnosed between 1980 and 2002.
  • Analysis of patient demographics, tumor location, size, and follow-up data.

Related Experiment Videos

  • Assessment of local, regional, and distant recurrence, as well as patient survival status.

    • Main Results:

    • No local recurrences were observed in the studied cases.
    • Three patients developed distant metastases, with a median time of 23 months post-diagnosis.
    • Two of the three metastatic patients died from the disease within an average of 22 months.
    • Disease-free survival rates were 68% at 2 years and 50% at 5 years.
    • Overall survival rates were 86% at 2 years and 68% at 5 years.

    Conclusions:

    • CCSTA is an aggressive soft-tissue tumor with a significant risk of distant disease development.
    • Aggressive surgical management is warranted due to the high risk of metastasis.
    • Neither multiagent chemotherapy nor radiotherapy demonstrated a significant impact on CCSTA outcomes in this series.