Related Experiment Video
Updated: Aug 24, 2026

Profiling of Permethylated Mucin O-glycans Using Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry
Published on: June 20, 2025
Effect of diet on mucin kinetics and composition: nutrition and health implications
L Montagne1, C Piel, J P Lallès
1Joint Unit of Research Calf and Pig, National Institute for Agricultural Research (INRA)/Agrocampus Rennes, 65 rue de Saint Brieuc, CS 84215, 35042 Rennes Cedex, France.
Abstract:
The mucus gel covering the gut epithelium is in dynamic balance between synthesis and secretion of mucin from goblet cells and proteolytic and physical erosion that releases mucin into the lumen. In the lumen, mucin is partially protected from proteolysis by carbohydrate chains, and it contributes to endogenous protein reaching the ileum. Dietary components modulate the contribution of mucin to endogenous protein components and their qualitative composition. In addition, mucin plays a key role in gastrointestinal protection in association with the microflora. In this review, we will attempt to evaluate the consequences of dietary manipulation of mucin on gut health.
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