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Plasminogen regulates pro-opiomelanocortin processing.

N Wang¹, L Zhang, L Miles

¹Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Lerner Research Institute, Cleveland, OH 44195, USA.

Journal of Thrombosis and Haemostasis : JTH

|April 22, 2004

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Plasminogen deficiency impairs the processing of stress-related hormones like beta-endorphin and alpha-melanocyte stimulating hormone. This hormonal imbalance affects normal brain function and stress responses in mice.

Area of Science:

Neuroendocrinology
Molecular Biology
Physiology

Background:

Plasminogen-deficient mice show altered stress responses, including a reduced acoustic startle reflex.
The acoustic startle reflex impacts the hypothalamic-pituitary axis and hormone regulation.

Purpose of the Study:

To determine if plasminogen influences hormone processing within the hypothalamic-pituitary axis.
Investigate the role of plasminogen in the regulation of stress hormones.

Main Methods:

Compared hormone concentrations and precursor processing in wild-type and plasminogen-deficient mice before and after acoustic startle reflex testing.
Analyzed plasma, pituitary, and brain tissues for specific hormones and their precursors.

Main Results:

Related Experiment Videos

Plasminogen deficiency led to significantly lower levels of beta-endorphin and alpha-melanocyte stimulating hormone in plasma, pituitary, and brain.
Plasmin demonstrated the ability to degrade pro-opiomelanocortin precursor peptides.
Restoring beta-endorphin and alpha-melanocyte stimulating hormone in plasminogen-deficient mice enhanced the acoustic startle reflex.

Conclusions:

Plasmin is crucial for processing pro-opiomelanocortin-derived hormones in the intermediate pituitary.
Reduced plasminogen function impairs beta-endorphin and alpha-melanocyte stimulating hormone processing, disrupting normal brain function and stress response.