Related Experiment Video
Updated: Aug 17, 2026
"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
Published on: February 19, 2019
[Preliminary study on proteomic patterns in hepatic tissue to identify HBV related hepatocellular carcinoma]
Yun-zhu Long1, Xue-gong Fan, Ning Li
1Department of Infectious Diseases, XiangYa Hospital, Central South University, Changsha 410008, China.
Objective:
To identify proteomic patterns in hepatic tissues for diagnosing early HBV related HCC.
Methods:
Proteomic spectra were generated by two-dimensional gel electrophoresis (2-DE), A preliminary "raining" set of spectra derived from analysis of 14 cancer tissues and 14 non-cancer tissues, a proteomic patterns that completely discriminated cancer from non-cancer was identified. The discovered pattern was then used to classify an independent set of 48 masked samples: 24 from cancer tissues, and 24 from non-cancer tissues.
Results:
The discriminatory pattern correctly identified all cancer tissues and non-cancer tissues in the masked set. This result yielded a sensitivity of 100%, specificity of 100%.
Conclusion:
Further analysis on these proteins in the proteomic pattern will be helpful to screen tumor markers for HBV related HCC. These findings justify a prospective assessment of proteomic pattern technology as a screening tool for cancer in high-risk and general populations.
