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Immunomodulation in asthma: a distant dream or a close reality?
Arpita Bharadwaj1, Devendra K Agrawal
1Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA.
International Immunopharmacology
|April 22, 2004
Summary
Discovering novel asthma treatments is advancing with a deeper understanding of disease pathogenesis. This review explores immune response regulation strategies, including anti-IgE therapy and cytokine antagonists, for allergic diseases.
Area of Science:
- Immunology
- Molecular Pathogenesis
- Allergic Diseases
Background:
- Asthma treatment research is ongoing.
- Understanding molecular pathogenesis enhances new treatment discovery.
- Immune response regulation offers therapeutic targets.
Purpose of the Study:
- To review strategies for regulating inappropriate immune responses in asthma.
- To highlight novel therapeutic approaches beyond current treatments.
Main Methods:
- Review of existing literature on asthma pathogenesis and treatment.
- Description of various immunomodulatory strategies.
- Analysis of omalizumab (anti-IgE antibody) as a successful example.
Main Results:
- Omalizumab (anti-IgE antibody) is a successful therapy.
- Cytokine antagonists, transcription factor antagonists, immunostimulatory DNA, cytokine therapy, and anti-T cell strategies show promise.
- These approaches offer alternative treatment options.
Conclusions:
- Multiple promising strategies exist for regulating immune responses in asthma.
- These novel therapies could provide alternatives for asthma and other allergic diseases.