Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Working memory capacity in schizophrenia: a parametric fMRI study.

J M Jansma1, N F Ramsey, N J A van der Wee

  • 1Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of health, 10 Center Drive, Bldg. 10, Room B1D118 MSC1065, Bethesda, MD 20892, USA.

Schizophrenia Research
|April 22, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

National survey of Dutch emergency physicians on pharmacological sedation practices for extreme agitation.

Toxicology reports·2026
Same author

Dietary Quality in Bipolar Disorder Compared to Unipolar Depression (Current and Remitted) and Healthy Controls: The Netherlands Study of Depression and Anxiety.

Bipolar disorders·2026
Same author

Inflammation, metabolic dysregulation, and depression profiles related to anhedonia and atypical, energy-related symptoms.

Brain, behavior, and immunity·2025
Same author

High-density electrocorticography reveals sensorimotor cortex engagement in two distinct sites with different roles during audiovisual, audio, and visual speech perception.

NeuroImage·2025
Same author

The effect of perceived auditory feedback on speech Brain-Computer Interface decoding performance.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2025
Same author

White matter connectivity in resilience in a general population sample of 12,516 individuals.

Neuroscience applied·2025
Same journal

Initiation patterns of long-acting injectable antipsychotics in a claims-based proxy cohort approximating first-episode schizophrenia: A longitudinal descriptive study using a Japanese claims database.

Schizophrenia research·2026
Same journal

Identifying in-the-moment alterations in socioemotional connection in youth at clinical high risk for psychosis and their caregivers via positivity resonance.

Schizophrenia research·2026
Same journal

Positive affect during social interactions predicts goal progress and social motivation in daily life for people with schizophrenia.

Schizophrenia research·2026
Same journal

Quality evaluation of randomized controlled trials of antipsychotic drugs for schizophrenia published in Chinese journals.

Schizophrenia research·2026
Same journal

FL-SDGIN: A federated graph learning approach for schizophrenia diagnosis integrating static and dynamic brain functional networks.

Schizophrenia research·2026
Same journal

Weight loss and gut microbial changes associated with semaglutide among people living with schizophrenia receiving clozapine or olanzapine: An open-label 24-week semaglutide intervention and 76-week trial.

Schizophrenia research·2026
See all related articles

Schizophrenia patients show normal brain activity increases with task difficulty, but peak activation occurs earlier. This suggests working memory (WM) dysfunction stems from impaired system output, not DLPFC pathology.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Working memory (WM) deficits are common in schizophrenia.
  • Abnormal dorsolateral prefrontal cortex (DLPFC) activation is linked to these deficits.
  • The cause of abnormal DLPFC activation (pathology vs. performance correlate) remains unclear.

Purpose of the Study:

  • To investigate the relationship between working memory load, performance, and brain activity in schizophrenia.
  • To determine if abnormal DLPFC activation reflects pathology or is a consequence of poor performance.

Main Methods:

  • Used a parametric functional magnetic resonance imaging (fMRI) design.
  • Employed a spatial N-back task with four increasing difficulty levels.
  • Compared brain activity in 10 schizophrenia patients (on atypical antipsychotics) and 10 healthy controls.

Related Experiment Videos

Main Results:

  • Schizophrenia patients exhibited progressively poorer performance with increasing task load.
  • Despite performance decline, DLPFC, inferior parietal cortex, and anterior cingulate activity increased normally with load in patients.
  • At the highest load (3-back), DLPFC activity decreased in patients compared to controls.

Conclusions:

  • Schizophrenia patients reach peak brain activation at lower processing loads than healthy controls.
  • WM dysfunction in schizophrenia likely results from impaired functional output of the entire WM system.
  • This impaired output elevates the effective cognitive burden, leading to performance deficits.