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Calcium channel blockers prevent stress-induced ulcers in rats
B C Yegen1, I Alican, A S Yalçin
1Department of Biochemistry, Marmara University, School of Medicine, Haydarpasa, Istanbul, Turkey.
Agents and Actions
|January 1, 1992
Abstract:
Gastric mucosal damage induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action.