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Updated: Aug 7, 2026

Skeletal Muscle Gender Dimorphism from Proteomics
Published on: December 14, 2011
Physiologic considerations for exercise performance in women
Nisha Charkoudian1, Michael J Joyner
1Department of Physiology, Mayo Clinic Rochester, 200 First Street Southwest, Rochester, MN 55905, USA. charkoudian.nisha@mayo.edu
Abstract:
Women exhibit several anatomic and physiologic characteristics that distinguish their responses to exercise from those of men. Women are smaller than men, have less muscle mass, and more fat mass for a given body size. Blood volume, stroke volume, and cardiac output are all lower in women than in men. These and other factors contribute to lower maximal aerobic power (even for similar training status) in women. The reproductive hormones, estrogen and progesterone, can influence ventilation, substrate metabolism, and thermoregulation during exercise. Women have a greater tendency for EIAH, which can limit VO2max as well as submaximal exercise performance at higher intensities. Women tend to use a greater percentage of fats during exercise, but also rely on CHOs. Thermoregulatory control is altered significantly over the course of the menstrual cycle by fluctuations in circulating levels of progesterone and estrogen. It is important for women to include regular exercise in their daily routines, particularly because regular physical activity has been implicated in the prevention of osteoporosis, breast cancer, heart disease, and depression.
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