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[Basic phospholipase of Naja nigricollis venom].
Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences. Serie D: Sciences Naturelles
|April 7, 1975
Summary
The N. nigricollis snake venom contains a toxic basic phospholipase A enzyme. This enzyme, similar to acidic forms, affects blood clotting and reacts with lecithin in vitro.
Area of Science:
- Biochemistry
- Toxicology
- Enzymology
Context:
- Naja nigricollis (N. nigricollis) snake venom composition.
- Identification and characterization of phospholipase enzymes in snake venom.
Purpose:
- To confirm the presence and properties of basic phospholipase A in N. nigricollis venom.
- To investigate the toxicological and biochemical activities of this enzyme.
Summary:
- N. nigricollis venom contains multiple phospholipases, including a toxic basic phospholipase A.
- This enzyme exhibits intravenous toxicity in mice and in vitro activity on lecithin, producing lysolecithin.
- Immunological studies reveal identity between the basic phospholipase A and two acidic phospholipases from the same venom.
Impact:
- Elucidates the enzymatic diversity and toxicological profile of N. nigricollis venom.
- Provides insights into the mechanisms of snake venom-induced anticoagulation.
- Contributes to understanding phospholipase structure-function relationships in venom research.