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Updated: Aug 6, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
Published on: October 15, 2013
Measurement of density and chemical concentration using a microfluidic chip
D Sparks1, R Smith, M Straayer
1Integrated Sensing Systems Inc, 391 Airport Industrial Dr, Ypsilanti, MI 48198, USA. dsparks@mems-issys.com
Abstract:
A new microfluidic product for measuring fluid density, specific gravity and chemical concentration has been developed. At the core of this lab-on-a-chip sensor is a vacuum-sealed resonating silicon microtube. Measurements can be made with under a microliter of sample fluid, which is over 1000x less than is conventionally required. Since the product is MEMS-based the overall system size is a fraction of conventional density meters and it weighs much less than the traditional desk-top, temperature controlled, density meters. The syringe or pipette loaded system includes a dynamic temperature control system that operates between 0 degree C and 90 degree C with an accuracy of less than 0.01 degree C. Density measurement accuracies of 4 to 5 digits have been observed with aqueous solutions. Measurement examples and applications will be discussed.

