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Updated: Aug 24, 2026
06:19
An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis
Published on: November 22, 2024
Investigation of racemisation in peptide synthesis within a micro reactor
Paul Watts1, Charlotte Wiles, Stephen J Haswell
1Department of Chemistry, University of Hull, Cottingham Road, Hull, UKHU6 7RX.
Lab on a Chip
|April 22, 2004
Abstract:
We demonstrate that peptides derived from alpha-amino acids may be prepared in a micro reactor. The peptides were prepared in 20 min with quantitative conversion, compared to batch reactions which require prolonged reaction times. We illustrate that by using dilute reagent concentrations and short reaction times, less racemisation is observed in micro reactions than in bulk reactions.
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