Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Menstrual function after tubal sterilization.

L S Wilcox1, B Martinez-Schnell, H B Peterson

  • 1Division of Reproductive Health, Centers for Disease Control, Atlanta, GA 30333.

American Journal of Epidemiology
|June 15, 1992
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of proton radiation dose, dose rate and dose fractionation on hematopoietic cells in mice.

Radiation research·2010
Same author

Work pattern causes bias in self-reported activity duration: a randomised study of mechanisms and implications for exposure assessment and epidemiology.

Occupational and environmental medicine·2008
Same author

Comments on 'Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond' by M. J. Pencina et al., Statistics in Medicine (DOI: 10.1002/sim.2929).

Statistics in medicine·2007
Same author

Countermeasures against space radiation induced oxidative stress in mice.

Radiation and environmental biophysics·2007
Same author

The protease inhibitor, Bowman-Birk Inhibitor, suppresses experimental autoimmune encephalomyelitis: a potential oral therapy for multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2007
Same author

Recall of a lead-contaminated vitamin and mineral supplement in a clinical trial.

Pharmacoepidemiology and drug safety·2004
Same journal

Correction to: Home dampness and molds and occurrence of respiratory tract infections in the first 27 years of life: the Espoo Cohort Study.

American journal of epidemiology·2026
Same journal

A SIMPLE AND POWERFUL TEST OF VACCINE WANING.

American journal of epidemiology·2026
Same journal

Association Between maternal body mass index, offspring growth and pubertal timing: results from a longitudinal birth cohort study.

American journal of epidemiology·2026
Same journal

Correction to: Developing a novel algorithm to identify incident and prevalent dementia in Medicare claims-the ARIC Study.

American journal of epidemiology·2026
Same journal

RE: advancing observational research on arts and health: theory-informed approaches using the RADIANCE framework.

American journal of epidemiology·2026
Same journal

Maternal Cesarean Section and Offspring ASD or ADHD Risk: A Nurses' Health Study II Analysis.

American journal of epidemiology·2026
See all related articles
This summary is machine-generated.

Tubal sterilization may lead to menstrual dysfunction, with increased pain and heavy bleeding reported by many women up to five years post-procedure. Early follow-up showed minimal changes, suggesting a delayed effect of sterilization on menstrual health.

Area of Science:

  • Reproductive Health
  • Gynecology
  • Surgical Outcomes

Background:

  • Tubal sterilization is a common procedure for female contraception in the US, with over 10 million women having undergone it.
  • Concerns exist regarding potential long-term menstrual dysfunction following tubal sterilization.
  • The Collaborative Review of Sterilization (CREST) study addresses these concerns through a large-scale, prospective investigation.

Purpose of the Study:

  • To analyze changes in menstrual cycle characteristics after tubal sterilization.
  • To determine if tubal sterilization is associated with increased risk of menstrual dysfunction.
  • To assess the timing of potential menstrual changes post-procedure.

Main Methods:

  • Prospective, multicenter study involving 5,070 women undergoing interval tubal sterilization.
Keywords:
Age FactorsAmericasBlacksContraceptionContraceptive Methods ChosenContraceptive UsageCultural BackgroundData AnalysisDemographic FactorsDeveloped CountriesDiseasesEconomic FactorsEducational StatusEthnic GroupsFamily PlanningFemale Sterilization--side effectsFertilityFertility MeasurementsFollow-up StudiesIntermediate VariablesMenstruation DisordersNorth AmericaNorthern AmericaPainParityPopulationPopulation CharacteristicsPopulation DynamicsResearch MethodologyResearch ReportSampling StudiesSigns And SymptomsSocioeconomic FactorsSocioeconomic StatusStatistical RegressionSterilization, SexualStudiesSurveysTime FactorsUnited StatesWhites

Related Experiment Videos

  • Data collected through interviews immediately before sterilization and annually for up to 5 years.
  • Longitudinal, multivariate regression analysis used to control for baseline function and confounders.
  • Main Results:

    • Five years post-sterilization, 35% reported high menstrual pain, 49% heavy flow, and 10% intermenstrual spotting.
    • In the first year, reported menstrual dysfunction rates were similar to pre-sterilization levels (27% pain, 41% heavy flow, 7% spotting).
    • A notable increase in menstrual dysfunction symptoms was observed between the first and fifth year follow-ups.

    Conclusions:

    • Tubal sterilization may be associated with the development or worsening of menstrual dysfunction over time.
    • Menstrual changes, if they occur, may not be apparent in the first year after sterilization.
    • Further research is needed to confirm these findings, considering potential cohort aging and study limitations.