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Updated: Aug 24, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Rapid enzymatic transglycosylation and oligosaccharide synthesis in a microchip reactor
Ken-ichi Kanno1, Hideaki Maeda, Showta Izumo
1Department of Bio-Environmental Chemistry, Kyushu School of Engineering, Kinki University, Kayanomori 11-6, Iizuka-shi, Fukuoka, 820-8555, Japan.
Abstract:
Glycosidase-promoted hydrolysis was performed in a microreaction channel. The result was compared with the reaction in a micro-test tube. Transgalactosylation on p-nitrophenyl-2-acetamide-2-deoxy-beta-D-glucopyranoside was also examined in a microreaction channel, because transglycosylation is a useful method for oligosaccharide synthesis. We examined both the forward reaction, i.e., hydrolysis, and the reverse reaction, i.e., transglycosylation, in the microreaction channel. The results showed that both hydrolysis and transglycosylation were enhanced in the microreaction channel compared with the batch reaction.
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