[Telithromycin]
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Updated: Aug 24, 2026

Assay Development for High-Throughput Drug Screening Against Mycobacteria
Published on: October 25, 2024
1Dept. Infect. Dis., 3rd Med. Faculty, Charles University, 18081 Prague 8, Czech Republic. benesj@cesnet.cz
Abstract:
For the time being telithromycin is the only representative of a new group of antibiotics - ketolides - available for clinical use. Its chemical structure is derived from erythromycin, but it is better resorbed from the digestive tract and is efficacious against most macrolide-resistant strains of Streptococcus pneumoniae and Streptococcus pyogenes. Telithromycin is registered for the treatment of respiratory infections: sinusitis, acute exacerbation of chronic bronchitis, community-acquired pneumonia and streptococcal tonsillopharyngitis. The drug is well tolerated. It is less likely to induce MLS(B) resistance than macrolides with a 14- or 15-member ring.
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