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Effectiveness of acetylcysteine on preventing renal dysfunction in patients undergoing coronary procedures

Shereif H Rezkalla1, Michele Benz

  • 1Marshfield Clinic, Department of Cardiology, Marshfield, Wis, USA. rezkalla.shereif@marshfieldclinic.org

WMJ : Official Publication of the State Medical Society of Wisconsin
|April 23, 2004
PubMed

Insights

Acetylcysteine preserves kidney function in patients undergoing coronary procedures. This study shows its benefit in routine clinical practice for patients with renal dysfunction.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Experimental studies suggest acetylcysteine benefits kidney function during cardiac procedures.
  • The role of acetylcysteine in routine clinical practice for renal protection is not well-established.

Purpose of the Study:

  • To evaluate the efficacy of acetylcysteine in preserving kidney function in patients with renal dysfunction undergoing coronary procedures in a clinical setting.

Main Methods:

  • A prospective study comparing 75 patients receiving acetylcysteine with 56 control patients undergoing coronary procedures.
  • All patients exhibited pre-existing renal dysfunction.
  • Procedures were performed by a single operator.

Main Results:

  • The acetylcysteine group showed a decrease in serum creatinine (-0.1 +/- 0.3 mg/dl) compared to a rise in the control group (0.2 +/- 0.6 mg/dl).
  • The beneficial effect of acetylcysteine on kidney function was observed across all degrees of renal dysfunction.

Conclusions:

  • Acetylcysteine, in addition to hydration, should be routinely adopted in clinical practice for patients with renal dysfunction undergoing coronary procedures.
  • This intervention is recommended for routine use in the cardiac catheterization laboratory.
Abstract

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