Intracranial angioplasty and stent placement for cerebral atherosclerosis

H Christian Schumacher1, Alexander V Khaw, Philip M Meyers

  • 1Doris and Stanley Tananbaum Stroke Center, Neurological Institute, New York-Presbyterian Hospital, College of Physicians & Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA.

Insights

Intracranial atherosclerotic stenoses cause 8-10% of ischemic strokes. For patients unresponsive to medical therapy, angioplasty with stent placement offers a viable option to prevent severe stroke.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Interventional Cardiology

Background:

  • Intracranial atherosclerotic stenoses (ICAS) contribute significantly to ischemic stroke incidence.
  • A notable proportion of patients with ICAS do not achieve optimal outcomes with current best medical management.

Purpose of the Study:

  • To review the pathophysiology of ICAS.
  • To discuss the role and considerations for endovascular revascularization in managing ICAS.

Main Methods:

  • Literature review of pathophysiologic concepts related to ICAS.
  • Analysis of endovascular treatment strategies for ICAS.

Main Results:

  • ICAS accounts for 8-10% of all ischemic strokes.
  • Medical treatment failure necessitates alternative strategies.

Conclusions:

  • Endovascular revascularization, including angioplasty with stent placement, is a reasonable therapeutic option for select patients with ICAS.
  • Understanding pathophysiologic mechanisms is crucial for successful endovascular intervention.