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Published on: October 20, 2017
Intracranial angioplasty and stent placement for cerebral atherosclerosis
H Christian Schumacher1, Alexander V Khaw, Philip M Meyers
1Doris and Stanley Tananbaum Stroke Center, Neurological Institute, New York-Presbyterian Hospital, College of Physicians & Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA.
Insights
Intracranial atherosclerotic stenoses cause 8-10% of ischemic strokes. For patients unresponsive to medical therapy, angioplasty with stent placement offers a viable option to prevent severe stroke.
Area of Science:
- Neurology
- Vascular Medicine
- Interventional Cardiology
Background:
- Intracranial atherosclerotic stenoses (ICAS) contribute significantly to ischemic stroke incidence.
- A notable proportion of patients with ICAS do not achieve optimal outcomes with current best medical management.
Purpose of the Study:
- To review the pathophysiology of ICAS.
- To discuss the role and considerations for endovascular revascularization in managing ICAS.
Main Methods:
- Literature review of pathophysiologic concepts related to ICAS.
- Analysis of endovascular treatment strategies for ICAS.
Main Results:
- ICAS accounts for 8-10% of all ischemic strokes.
- Medical treatment failure necessitates alternative strategies.
Conclusions:
- Endovascular revascularization, including angioplasty with stent placement, is a reasonable therapeutic option for select patients with ICAS.
- Understanding pathophysiologic mechanisms is crucial for successful endovascular intervention.
Abstract:
Intracranial atherosclerotic stenoses have been estimated to account for 8%-10% of all ischemic strokes. A substantial number of patients fail the best medical treatment, which includes control of vascular risk factors and administration of antithrombotics (platelet-active drugs or warfarin), statins, and angiotensin-converting enzyme inhibitors. In these patients, angioplasty with stent placement is one reasonable treatment option for preventing massive ischemic stroke. Herein, we discuss basic pathophysiologic concepts and their effect on endovascular revascularization procedures.
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