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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
Published on: September 1, 2019
The role of cyclic-AMP binding protein (CREB) in leukemia cell proliferation and acute leukemias
Deepa B Shankar1, Kathleen M Sakamoto
1Division of Hematology-Oncology, Gwynne-Hazen Cherry Memorial Laboratories, Mattel Children's Hospital, Los Angeles, CA 90095-1752, USA.
Abstract:
Leukemia is a result of accumulating genetic alterations. The collaboration of mutations that offer survival and proliferative signals, together with mutations that result in lack of differentiation, is thought to cause a leukemic phenotype. The cyclic-AMP Response Element Binding Protein (CREB) is a transcription factor that is known to be a downstream component of the GM-CSF and IL-3 signaling pathways. We previously showed that CREB is overexpressed in blast cells from patients with acute leukemias. In this paper, we review the role of CREB in hematopoiesis, cell proliferation and acute leukemias.
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