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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
A strategy for exploiting the pseudosymmetry of the C1-C13 stretch of discodermolide
Kathlyn A Parker1, Ioannis A Katsoulis
1Department of Chemistry, State University of New York at Stony Brook Stony Brook, New York 11794-3400, USA. kparker@notes.cc.sunysb.edu
Abstract:
[reaction: see text] The pseudo-C(2)() symmetry of the C1 to C13 stretch of the discodermolide structure offers a potential strategic advantage for synthetic design. Two approaches based on this recognition were devised, and one was shown to be effective in a model series.
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