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Updated: Aug 24, 2026

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
Published on: February 14, 2021
Differential analysis in the time domain of the baroreceptor cardiac reflex sensitivity as a function of sequence
Gustavo A Reyes del Paso1, José A Hernández, M Isabel González
1Department of Psychology, University of Jaén, Jaén, Spain. greyes@ujaen.es
Abstract:
Analysis of baroreceptor sensitivity (BRS) in the time domain through the spontaneous sequence method used a measure of BRS based on the average of all sequences detected, without making any distinction in cardiac cycle length. In this article, we study differentially the functioning of the baroreflex as a function of the length of the cardiac sequences (3, 4, 5, or 6 cardiac cycles). One hundred and four students performed three mental stress tasks: mental arithmetic, memory, and visual attention. The results show that (1) as sequence length decreases, the relationships between BRS and indexes of vagal cardiac control increase, (2) the BRS associated with the more short sequences (3 and 4 beats) is the most vulnerable to mental stress, particularly the mental arithmetic task, and (3) BRS increases progressively as sequence length decreases. These results suggest that the nature and functioning of the baroreflex differ as a function of the length of the cardiac sequences.
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In contrast, nonlinear systems do not inherently possess these properties. However, for small deviations around an operating point, a nonlinear system can often be approximated as linear.

