Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

I-proteins - a proposed switch in myotubularin function.

Michael J Clague1, Stephen K Dove, Francis A Barr

  • 1Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK. clague@liv.ac.uk

Trends in Biochemical Sciences
|April 23, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation.

Life science alliance·2026
Same author

Pexophagy meets physiology.

The Journal of cell biology·2025
Same author

Béla Novák (1956-2025) - a legacy of scientific discovery and personal charm.

Journal of cell science·2025
Same author

Proteostasis of immune checkpoint receptors.

The Biochemical journal·2025
Same author

A pivot-tether model for nucleosome recognition by the chromosomal passenger complex.

EMBO reports·2025
Same author

Time as a danger signal promoting G1 arrest after mitosis.

Trends in cell biology·2025

Myotubularins, a class of enzymes, may have functions beyond regulating lipid levels. They might also act like G-protein phosphatases, using nucleotide-dependent changes to signal or perform mechanical work.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Cell Signaling

Background:

  • Myotubularins are a large family of phosphoinositide 3-phosphatases.
  • Previously, their function was thought to be solely regulating lipid substrate levels, similar to PTEN (phosphatase and tensin homolog deleted in chromosome ten).

Purpose of the Study:

  • To propose an alternative or additional function for myotubularins.
  • To explore their potential role analogous to G-protein phosphatases.

Main Methods:

  • Comparative analysis of myotubularin structure and function with known phosphatases.
  • Hypothesizing mechanisms based on protein phosphatase families.

Main Results:

  • Myotubularins may possess functions beyond simple substrate level regulation.

Related Experiment Videos

  • A proposed function involves nucleotide-dependent conformational changes, similar to G-protein phosphatases.

    • Conclusions:

    • Myotubularins could play a role in signal transduction or mechanical work.
    • This expands the known functional repertoire of phosphoinositide 3-phosphatases.