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Related Experiment Videos

In search of antisense.

Giovanni Lavorgna1, Dvir Dahary, Ben Lehner

  • 1Human Molecular Genetics Unit, Dibit-San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy. giovanni.lavorgna@hsr.it

Trends in Biochemical Sciences
|April 23, 2004
PubMed
Summary

Natural antisense transcripts (NATs) regulate gene expression through diverse mechanisms. Research is uncovering their role in human diseases, with ~2500 mammalian NATs identified to date.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Natural antisense transcripts (NATs) are increasingly recognized for their roles in eukaryotic gene expression.
  • NATs are involved in processes like genomic imprinting, RNA interference, and translational regulation.
  • Emerging evidence links antisense transcription to various human diseases.

Purpose of the Study:

  • To highlight the growing importance of natural antisense transcripts in gene regulation.
  • To underscore the potential involvement of NATs in human pathologies.
  • To review current efforts in identifying novel NATs and discuss future research directions.

Main Methods:

  • Literature review of recent studies on NATs.
  • Bioinformatic analysis of identified mammalian NATs.

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  • Synthesis of evidence linking NATs to human diseases.

    • Main Results:

    • Approximately 2500 mammalian NATs have been identified.
    • Antisense transcription represents a common gene expression regulatory mechanism in humans.
    • Diverse mechanisms of gene regulation by NATs are being discovered.

    Conclusions:

    • NATs play multifaceted roles in gene expression.
    • Antisense transcription is a significant factor in human health and disease.
    • Bioinformatic tools are crucial for advancing NAT research.