Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic variability in CYP3A5 and its possible consequences.

Hong-Guang Xie1, Alastair J J Wood, Richard B Kim

  • 1Vanderbilt University School of Medicine, Nashville, TN 37232, USA. hong-guang.xie@vanderbilt.edu

Pharmacogenomics
|April 23, 2004
PubMed
Summary

Cytochrome P450 3A5 (CYP3A5) genetic variations significantly influence drug metabolism due to high expression variability. This review details CYP3A5 polymorphisms and their impact on drug response across diverse populations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum Isolevuglandin IgG Antibody Concentrations Are Increased in Patients with Systemic Lupus Erythematosus and Associated with Lower 24-Hour Blood Pressure.

Frontiers in lupus·2026
Same author

Synthesis and Reactivity of Heteroleptic U<sup>4+</sup> Alkyl, Benzyl, and Hydride Imidophosphorane Complexes.

Inorganic chemistry·2026
Same author

ImmuSeeker: deep mining of immune-related gene family signatures through lineage reconstruction.

Genome biology·2026
Same author

A Mendelian randomization-based drug repurposing pipeline: application to lipid traits and coronary artery disease.

medRxiv : the preprint server for health sciences·2026
Same author

Association of Clonal Hematopoiesis With Incident, Late-Onset, Seropositive Rheumatoid Arthritis.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Zn-flux-enabled synthesis of orthorhombic kagome YbFe<sub>6</sub>Ge<sub>6</sub>: Yb reduction and magnetic behavior.

Chemical communications (Cambridge, England)·2026

Area of Science:

  • Pharmacogenomics
  • Drug Metabolism
  • Enzyme Kinetics

Background:

  • Cytochrome P450 3A (CYP3A) enzymes are crucial for drug metabolism in humans.
  • Interindividual variability in CYP3A activity is significant but not fully explained by CYP3A4 genetic variants.
  • CYP3A5 expression variability is a potential contributor to differences in drug metabolism.

Purpose of the Study:

  • To review current data on CYP3A5 polymorphisms.
  • To analyze the population frequency of CYP3A5 genetic variants in major ethnic groups.
  • To summarize in vitro and in vivo studies investigating CYP3A5 genotype-phenotype associations.

Main Methods:

  • Literature review of published studies on CYP3A5.
  • Analysis of population genetics data for CYP3A5 variants.

Related Experiment Videos

  • Compilation of findings from in vitro and in vivo experimental studies.

    • Main Results:

    • Detailed collation of known CYP3A5 genetic polymorphisms.
    • Presentation of ethnic-specific frequencies for various CYP3A5 alleles.
    • Summary of genotype-phenotype correlations from experimental studies.

    Conclusions:

    • CYP3A5 genetic polymorphisms are important determinants of drug metabolism variability.
    • Understanding CYP3A5 variants is essential for predicting drug response and optimizing pharmacotherapy.
    • Further research is needed to fully elucidate the clinical impact of CYP3A5 genotype on drug efficacy and safety.