The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice
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11:32
Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
Riccardo Manganelli1, Lanfranco Fattorini, Dejiang Tan
1Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy.
Infection and Immunity
|April 23, 2004
Abstract:
The virulence of a Mycobacterium tuberculosis H37Rv sigE mutant was studied in immunodeficient and immunocompetent mice. The mutant was strongly attenuated in both animal models and induced formation of granulomas with different characteristics than those induced by the wild-type strain.
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