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Phorbasterones A-D, cytotoxic nor-ring A steroids from the sponge Phorbas amaranthus
Makoto N Masuno1, Joseph R Pawlik, Tadeusz F Molinski
1Department of Chemistry, University of California, Davis, California 95616, USA.
Journal of Natural Products
|April 24, 2004
Abstract:
The sponge Phorbas amaranthus from Florida contains the new ring A-contracted steroids, phorbasterones A-D, and the known anthosterones A and B. The structures of phorbasterones A-D were determined by interpretation of their spectroscopic data. Phorbasterones show moderate cytotoxicity against HCT-116 tumor cells.