Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progress toward skeletal gene therapy.

Henry J Klamut1, Shin-Tai Chen, K-H William Lau

  • 1Departments of Medicine and Biochemistry, Loma Linda University and the Musculoskeletal Disease Center (151), Jerry L. Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA.

Critical Reviews in Eukaryotic Gene Expression
|April 24, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of Feasibility of the M2 Macrophage-Based Adoptive Gene Transfer Strategy for Osteoarthritis with a Mouse Model.

Cells·2025
Same author

Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangement.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy·2025
Same author

Conditional Deletion of Gremlin-1 in Cathepsin K-expressing Mature Osteoclasts Altered the Skeletal Response to Calcium Depletion in Sex-Dependent Manner.

Calcified tissue international·2025
Same author

Development of a Competitive Nutrient-Based T-Cell Immunotherapy Designed to Block the Adaptive Warburg Effect in Acute Myeloid Leukemia.

Biomedicines·2024
Same author

1,25-Dihydroxyvitamin D Enhances the Regenerative Function of Lgr5<sup>+</sup> Intestinal Stem Cells In Vitro and In Vivo.

Cells·2024
Same author

Discovery of NFκB2-Coordinated Dual Regulation of Mitochondrial and Nuclear Genomes Leads to an Effective Therapy for Acute Myeloid Leukemia.

International journal of molecular sciences·2024

Skeletal gene therapy offers a promising new way to treat bone disorders by using gene expression to enhance bone repair. Future research aims to refine gene targets and delivery methods for safer, more effective treatments.

Area of Science:

  • Regenerative Medicine
  • Molecular Biology
  • Orthopedics

Background:

  • Advances in understanding the genetic basis of bone disorders and fracture healing have enabled novel therapeutic strategies.
  • Skeletal gene therapy utilizes ectopic gene expression in patient cells to influence bone repair and regeneration.
  • Proof-of-principle for enhanced bone formation via skeletal gene therapy has been established, marking a significant step forward.

Purpose of the Study:

  • To review recent advances in skeletal gene therapy, particularly for localized bone lesions.
  • To discuss the strengths and weaknesses of current gene therapy approaches for bone disorders.
  • To explore strategies for enhancing the safety and therapeutic outcomes of future skeletal gene therapy interventions.

Main Methods:

Related Experiment Videos

  • Review of recent scientific literature on skeletal gene therapy.
  • Analysis of molecular genetic insights into bone disorders and fracture healing.
  • Discussion of gene delivery technologies and cellular targets for skeletal gene therapy.

    • Main Results:

    • Skeletal gene therapy has demonstrated potential for enhanced bone formation.
    • Current approaches require further refinement in cellular targets and gene selection.
    • Safe and efficient gene delivery methods are critical for clinical success.

    Conclusions:

    • Skeletal gene therapy holds significant promise for improving patient care in bone disorders.
    • The next five years offer opportunities to develop more effective therapeutic strategies.
    • Overcoming challenges in current gene transfer technologies is key to realizing the full potential of skeletal gene therapy.