Related Experiment Video
Updated: Aug 24, 2026

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice
Published on: November 13, 2016
Biological osteosynthesis versus traditional anatomic reconstruction of 20 long-bone fractures using an interlocking
Christopher L Horstman1, Brian S Beale, Michael G Conzemius
1Orthopedic Research Laboratory, Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA. horstman@cvm.msstate.edu
Objective:
To observe differences in surgical and healing times as well as complication rates in dogs with a comminuted long-bone fracture stabilized with an interlocking nail (IN) using either anatomic or biologic repair.
Study Design:
Retrospective study.
Animals:
Twenty client-owned dogs with comminuted long-bone fractures.
Methods:
Medical records for dogs with fractures repaired during a 7-year period were reviewed; 20 dogs had repair with an IN nail and radiographic evidence of healing. These 20 dogs where divided into 2 groups, anatomic (11 dogs) and biological (9) repair, for statistical evaluation. Surgical and healing time and complication rates were compared between groups.
Results:
Median surgical times were: anatomic (95 minutes) and biologic (110 minutes; P=.06). Median healing times were anatomic (8 weeks) and biologic (6 weeks; P=.04). No statistical differences were observed in complication rates (the likelihood that a case required a second surgery [P=.58], the likelihood of a complication that was managed non-surgically [P=.27]). Use of a bone graft did not shorten healing times (P=.55).
Conclusions:
Biological osteosynthesis provides clinical advantages over anatomic reconstruction with respect to a reduction in surgical and healing time without increasing complication rates.
Clinical Relevance:
Highly comminuted long-bone fractures can be successfully repaired using an IN without reconstructing the fracture fragments in dogs.
More Related Videos
07:35Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
Published on: April 11, 2012
04:41Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner
Published on: June 6, 2025