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Published on: September 21, 2021
Synthesis of (2S,3R)-[3',3',3'-2H3]-valine and (2S,3S)-4-fluorovaline
Jean-Damien Charrier1, Peter B Hitchcock, Douglas W Young
1Sussex Centre for Biomolecular Design and Drug Discovery, Department of Chemistry, University of Sussex, Falmer, Brighton, UK BN1 9QJ.
Organic & Biomolecular Chemistry
|April 24, 2004
Abstract:
A new synthesis of (2S,3R)-[3',3',3'-2H3]-valine has been completed and (2S,3S)-4-fluorovaline has been synthesised for the first time. Both compounds have been prepared by routes involving stereoselective addition to the (S)-pyroglutamate derivative and are available for studies in several areas of bio-organic chemistry.

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