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Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain
Published on: July 18, 2016
Successful use of zonisamide for central poststroke pain
Yuji Takahashi1, Kouichi Hashimoto, Shoji Tsuji
1Department of Neurology, Toshiba Hospital, Tokyo, Japan. TAKAHASHIY-INT@h.u-tokyo.ac.jp
Unlabelled:
We present 2 patients with severe and intractable central poststroke pain (CPSP) after right posterolateral thalamic infarcts who were successfully treated with zonisamide. The mechanism of action was presumed to be the suppression of overacting thalamic relay neurons by blockade of low voltage-activated calcium channel or by increasing gamma-aminobutyric acid (GABA) release. Zonisamide can be one of the therapeutic options for severe CPSP and might provide an insight into the pathogenesis of CPSP.
Perspective:
The blockade of T-type VGCC or the increase in GABA release caused by zonisamide presumably suppresses abnormal activities of thalamic sensory neurons.
