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Related Experiment Videos

Probiotics for treating infectious diarrhoea.

S J Allen1, B Okoko, E Martinez

  • 1Swansea Clinical School, University of Wales Swansea, Grove Building, Swansea, West Glamorgan, UK, SA2 8PP.

The Cochrane Database of Systematic Reviews
|April 24, 2004
PubMed
Summary

Probiotics significantly reduce the duration and severity of acute infectious diarrhea in adults and children. These beneficial microorganisms offer a safe and effective complementary therapy alongside rehydration.

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Public Health

Background:

  • Probiotics are live microbial cultures conferring health benefits to the host.
  • They represent a potential safe intervention for acute infectious diarrhea, aiming to reduce illness duration and severity.

Purpose of the Study:

  • To systematically evaluate the efficacy of probiotics in treating acute infectious diarrhea.

Main Methods:

  • Conducted a comprehensive literature search across multiple databases (Cochrane, MEDLINE, EMBASE) and contacted experts.
  • Included randomized controlled trials comparing probiotics with placebo in patients with infectious diarrhea.
  • Two independent reviewers assessed study quality and extracted data.

Main Results:

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  • Analyzed 23 studies with 1917 participants; heterogeneity was observed across studies.
  • Probiotics demonstrated a significant reduction in diarrhea risk at 3 days (RR 0.66, 95% CI 0.55-0.77).
  • Mean diarrhea duration was reduced by approximately 30.5 hours (95% CI 18.51-42.46).

Conclusions:

  • Probiotics are a beneficial addition to rehydration therapy for acute infectious diarrhea in both adults and children.
  • Further research is warranted to determine optimal probiotic strains and regimens for specific populations.