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Related Experiment Videos

Interventions for impetigo.

S Koning1, A P Verhagen, L W A van Suijlekom-Smit

  • 1Department of General Practice, Erasmus MC - University Medical Center Rotterdam, Room Ff337, PO Box 1738, Rotterdam, Netherlands, 3000 DR.

The Cochrane Database of Systematic Reviews
|April 24, 2004
PubMed
Summary
This summary is machine-generated.

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Topical antibiotics like mupirocin and fusidic acid are effective for impetigo, showing better cure rates than placebo. Oral antibiotics may cause more side effects than topical treatments.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Impetigo is a common superficial bacterial skin infection, particularly in children.
  • Current treatment guidelines for impetigo vary, with options including oral and topical antibiotics, and disinfectants.

Purpose of the Study:

  • To evaluate the effectiveness of various impetigo treatments, including natural resolution.
  • To compare different oral and topical antibiotic therapies and disinfectants.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) identified through extensive database searches and hand-searching.
  • Included trials focused on non-bullous and bullous, primary and secondary impetigo.
  • Data collection and quality assessment were performed by two independent reviewers.

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Main Results:

  • Topical antibiotics demonstrated superior cure rates compared to placebo.
  • Topical mupirocin and fusidic acid showed comparable efficacy, with mupirocin being more effective than oral erythromycin.
  • Oral antibiotic treatment was associated with a higher incidence of side effects, particularly gastrointestinal issues, compared to topical treatments.

Conclusions:

  • Topical mupirocin and fusidic acid are effective for limited impetigo, with efficacy similar to or better than oral treatments.
  • Evidence regarding the natural course of impetigo and the efficacy of disinfectants is limited.
  • Antibiotic resistance patterns necessitate careful consideration when selecting impetigo therapies.