Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Beta-adrenoceptor polymorphisms and heart failure.

Martin J Lohse1

  • 1Institue for Pharmacology and Toxicology, University of Wuerzburg, Germany. lohse@toxi.uni-wuerzburg.de

Trends in Molecular Medicine
|April 27, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors.

bioRxiv : the preprint server for biology·2026
Same author

GPR3 Ligands Discovered through Combined Virtual and Conformational Biosensor-Based Screening.

Journal of the American Chemical Society·2026
Same author

Ligand-specific activation trajectories dictate GPCR signalling in cells.

Nature·2026
Same author

MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor.

Nature communications·2025
Same author

Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Pharmacological characterization of a clinical candidate, TG-0054, a small molecule inverse agonist targeting CXCR4.

Molecular pharmacology·2025
Same journal

Hyocholic acids: Third bile acids for neonatal health.

Trends in molecular medicine·2026
Same journal

Clonal hematopoiesis in Alzheimer's brain: Protective, pathogenic, and context-dependent?

Trends in molecular medicine·2026
Same journal

Targeting amino acid metabolism in hepatocellular carcinoma.

Trends in molecular medicine·2026
Same journal

Turning perfusion into repair through ferroptosis blockade.

Trends in molecular medicine·2026
Same journal

CaMKK2: A tumor stress-integration node.

Trends in molecular medicine·2026
Same journal

Precision gene editing: From proof-of-concept to curative therapies.

Trends in molecular medicine·2026
See all related articles

Adrenoceptor gene variations may impact heart health and beta-blocker effectiveness, but complex genetic combinations require further study due to limited patient data.

Area of Science:

  • Pharmacogenomics
  • Cardiovascular Research
  • Molecular Biology

Background:

  • Polymorphisms in beta 1, beta 2, and alpha 2c-adrenoceptor genes are known.
  • These genetic variations can alter receptor signaling and regulation.
  • Previous studies on adrenoceptor function in cardiovascular health have produced inconsistent results.

Purpose of the Study:

  • To investigate the impact of adrenoceptor gene polymorphisms on cardiovascular function.
  • To explore potential links between these polymorphisms and heart failure risk or beta-blocker treatment response.
  • To highlight the need for investigating complex genetic haplotypes.

Main Methods:

  • Review of existing literature on adrenoceptor gene polymorphisms.
  • Analysis of studies examining cardiovascular effects in humans and mice.

Related Experiment Videos

  • Assessment of reported associations with heart failure and beta-blocker therapy.

    • Main Results:

    • Mixed results exist regarding the cardiovascular impact of individual adrenoceptor polymorphisms.
    • Some evidence suggests a role in heart failure risk and beta-blocker response.
    • Complex haplotypes (combinations of polymorphisms) remain largely unexamined.

    Conclusions:

    • Current evidence on adrenoceptor polymorphisms and cardiovascular function is inconclusive.
    • Further research is needed to understand the role of complex haplotypes.
    • Larger patient cohorts are required to draw firm conclusions and make clinical recommendations.