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Updated: Aug 24, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
[Non-revascularisation of acute coronary syndrome with ST elevation]
M Zeller1, G Dentan, K Hadj Hamou
1Service de cardiologie, CHU Bocage, Dijon.
Insights
Revascularisation strategies for acute coronary syndromes (ACS) need updating. Elderly patients and those with left bundle branch block or delayed admission require tailored approaches for better outcomes.
Area of Science:
- Cardiology
- Public Health
Background:
- Acute coronary syndromes (ACS) management requires updated therapeutic strategies, particularly for reperfusion.
- The RICO observatory in Côte d'Or tracked ACS cases to evaluate regional treatment effectiveness.
Purpose of the Study:
- To re-evaluate national therapeutic strategies for acute coronary syndromes (ACS) focusing on reperfusion.
- To identify factors influencing reperfusion success in ACS patients.
Main Methods:
- A review of 706 ACS patients admitted between January 2001 and April 2003 with ST elevation or left bundle branch block.
- Analysis of reperfusion methods (thrombolysis vs. primary angioplasty) and patient characteristics.
Main Results:
- 69% of eligible ACS patients received reperfusion; thrombolysis was most common (66%).
- Independent predictors of non-reperfusion included age (≥75 years), left bundle branch block, and admission >6 hours post-symptom onset.
- Significant delays in hospital admission and specific patient demographics impacted reperfusion rates.
Conclusions:
- Developing regional networks can improve ACS management efficiency and reduce admission delays.
- Specific therapeutic strategies for coronary revascularisation in ACS are needed for vulnerable groups, such as the elderly.
Abstract:
National therapeutic strategies in acute coronary syndromes (ACS) required revaluation, especially with regards to reperfusion. RICO is an observatory of ACS in the Côte d'Or district. Between January 1st 2001 and April 31st 2003, the cases of 706 patients with ACS and persistent ST elevation or appearances of left bundle branch block eligible for revascularisation (admitted < 12 hours after onset of symptoms and no contra-indications to thrombolysis), were reviewed. The number of revascularised patients was 488 (69%) and 218 (31%) were not revascularised. Thrombolysis was the most commonly used method of revascularisation (66%) in this district: 34% underwent primary angioplasty. Multivariate analysis showed only three independent predictive factors of non-reperfusion during the acute phase. They were: age (> or = 75 years) (p < 0.001), left bundle branch block (p = 0.002) and hospital admission > or = 6 hours after onset of symptoms (p < 0.001). These results confirm the utility of developing networks to improve the efficacy of management and reduce the delay before hospital admission. They also identify specific population groups, the elderly for example, who require specific therapeutic strategies for coronary revascularisation in ACS.
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Acute Coronary Syndrome I: Introduction
Acute Coronary Syndrome III: Diagnostic Studies
