Jove
Visualize
Contact Us

Related Experiment Videos

Diabetic cardiomyopathy.

D Feuvray1

  • 1Unité mixte de recherche CNRS 8078, Université Paris-Sud XI, département de recherche médicale, hôpital Marie Lannelongue, Le Plessis-Robinson. danielle.feuvray@ibaic.upsud.fr

Archives Des Maladies Du Coeur Et Des Vaisseaux
|April 27, 2004
PubMed
Summary

Diabetic cardiomyopathy involves altered cardiac energy metabolism, with the diabetic heart relying heavily on fatty acids due to reduced glucose utilization. This shift can lead to metabolic dysfunction and heart problems.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diabetes-related metabolic perturbations in cardiac myocyte.

Diabetes & metabolism·2008
Same author

Enhanced activity of the myocardial Na+/H+ exchanger contributes to left ventricular hypertrophy in the Goto-Kakizaki rat model of type 2 diabetes: critical role of Akt.

Diabetologia·2007
Same author

Intracellular sodium increase and susceptibility to ischaemia in hearts from type 2 diabetic db/db mice.

Diabetologia·2006
Same author

Intracellular sodium in the ischemic and reperfused heart and its role in injury.

Magma (New York, N.Y.)·2001
Same author

Changes in intracellular sodium and pH during ischaemia-reperfusion are attenuated by trimetazidine. Comparison between low- and zero-flow ischaemia.

Cardiovascular research·2000
Same author

Slowly inactivating component of sodium current in ventricular myocytes is decreased by diabetes and partially inhibited by known Na(+)-H(+)Exchange blockers.

Journal of molecular and cellular cardiology·2000
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Cardiology
  • Metabolic Diseases
  • Biochemistry

Background:

  • Diabetic cardiomyopathy pathogenesis is unclear, but cardiac energy metabolism is implicated.
  • The normal heart uses fatty acids and glucose for energy, adapting to different conditions.
  • Insulin regulates myocardial metabolism; deficiency/resistance reduces glucose use in the diabetic heart.

Purpose of the Study:

  • To investigate the role of altered cardiac energy metabolism in diabetic cardiomyopathy.
  • To understand how insulin deficiency/resistance impacts myocardial energy substrate utilization.
  • To explore the consequences of altered fuel preference in the diabetic heart.

Main Methods:

  • Analysis of cardiac energy metabolism in diabetic models.
  • Assessment of glucose and fatty acid utilization pathways in the myocardium.
  • Investigation of lipid intermediate accumulation and oxygen consumption rates.

Main Results:

  • Diabetic hearts show significantly reduced glucose utilization.
  • The diabetic heart relies almost exclusively on fatty acid oxidation for energy.
  • High fatty acid utilization may cause functional issues due to lipid intermediate buildup and increased oxygen demand.

Conclusions:

  • Chronic derangements in myocardial metabolism are central to diabetic cardiomyopathy.
  • Impaired intracellular signaling pathways contribute to maladaptive consequences.
  • Altered energy metabolism, particularly increased fatty acid reliance, leads to functional abnormalities in the diabetic heart.

Related Experiment Videos