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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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Topiramate attenuates withdrawal signs after chronic intermittent ethanol in rats

Elisabetta Cagetti1, Kate J Baicy, Richard W Olsen

  • 1Department of Molecular and Medical Pharmacology, School of Medicine, University of California, Room CHS 23-120, 650 Young Drive South, Los Angeles, CA 90095, USA.

Neuroreport
|April 27, 2004
PubMed

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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...