Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The blood-retinal barriers system. Basic concepts and clinical evaluation.

José G Cunha-Vaz1

  • 1Department of Ophthalmology, Faculty of Medicine, Centre of Ophthalmology, Institute of Biomedical Research on Light and Image, University of Coimbra, and AIBILI, Coimbra, Portugal. cunhavaz@aibili.pt

Experimental Eye Research
|April 27, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Different Risk Profiles for Progression of Nonproliferative Diabetic Retinopathy: A 2-Year Study.

Ophthalmology and therapy·2022
Same author

Efficacy and Safety of Intravitreal Aflibercept Treat and Extend for Polypoidal Choroidal Vasculopathy in the ATLANTIC Study: A Randomized Clinical Trial.

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde·2021
Same author

Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR.

The British journal of ophthalmology·2020
Same author

MEASUREMENTS OF RETINAL FLUID BY OPTICAL COHERENCE TOMOGRAPHY LEAKAGE IN DIABETIC MACULAR EDEMA: A Biomarker of Visual Acuity Response to Treatment.

Retina (Philadelphia, Pa.)·2017
Same author

OPTICAL COHERENCE TOMOGRAPHY BASELINE PREDICTORS FOR INITIAL BEST-CORRECTED VISUAL ACUITY RESPONSE TO INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR TREATMENT IN EYES WITH DIABETIC MACULAR EDEMA: The CHARTRES Study.

Retina (Philadelphia, Pa.)·2017
Same author

Changes in reticular pseudodrusen area in eyes that progressed from early to late age-related macular degeneration.

International ophthalmology·2017
Same journal

Comparative analyses of the differentiation and stemness status of corneal epithelial cell lines in varying culture conditions.

Experimental eye research·2026
Same journal

Corneal deformation mapping and FE-based strain analysis via digital image correlation: Biomechanical changes after CXL and laser refractive surgery.

Experimental eye research·2026
Same journal

Tanshinone IIA inhibits choroidal neovascularization and restores outer blood-retinal barrier function in Vldlr knockout mice.

Experimental eye research·2026
Same journal

Understanding the ocular accumulation of mefuparib and its N-dealkylation metabolite: Pharmacokinetics, melanin affinity, and cellular disposition.

Experimental eye research·2026
Same journal

Mitochondrial Dysfunction and Diabetic Retinopathy: Research Progress from Pathogenic Mechanisms to Therapeutic Targets.

Experimental eye research·2026
Same journal

Middle-wavelength green ambient light attenuates lens-induced myopia progression and is associated with suppression of the Wnt/β-catenin signaling pathway in guinea pigs.

Experimental eye research·2026
See all related articles

The Blood-Retinal Barrier (BRB) regulates retinal function. New tools like the Retinal Leakage Analyzer map BRB alterations, aiding disease diagnosis and drug evaluation for retinal conditions.

Area of Science:

  • Ophthalmology
  • Cell Biology
  • Physiology

Background:

  • The Blood-Retinal Barrier (BRB) comprises endothelial cells with tight junctions, regulating retinal microenvironment.
  • BRB integrity is crucial for maintaining retinal function and vision.
  • Alterations in BRB are implicated in various retinal diseases.

Purpose of the Study:

  • To review the concept and role of the Blood-Retinal Barrier (BRB).
  • To discuss methods for evaluating BRB function, including vitreous fluorometry.
  • To highlight advancements in mapping BRB alterations and their clinical implications.

Main Methods:

  • Morphological studies of retinal vessels and endothelial cell tight junctions ('zonulae occludente').
  • Physiological studies using fluorescein diffusion gradients in the vitreous.

Related Experiment Videos

  • Vitreous fluorometry for evaluating BRB diffusional and transport functions.
  • Introduction of the Retinal Leakage Analyzer for mapping BRB alterations.

    • Main Results:

    • Established the foundational concept of the Blood-Retinal Barrier (BRB).
    • Vitreous fluorometry demonstrated the importance of BRB alterations in retinal diseases.
    • Limited disease specificity of previous methods was noted.
    • The Retinal Leakage Analyzer offers improved mapping and evaluation capabilities.

    Conclusions:

    • The BRB is fundamental for retinal health and function.
    • Vitreous fluorometry is a valuable tool but lacks disease specificity.
    • The Retinal Leakage Analyzer represents a significant advancement for multimodal macula mapping.
    • New technologies enhance the evaluation of drugs aimed at stabilizing the BRB.