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Updated: Aug 14, 2026

Locked Nucleic Acid Flow Cytometry-fluorescence in situ Hybridization (LNA flow-FISH): a Method for Bacterial Small RNA Detection
09:45

Locked Nucleic Acid Flow Cytometry-fluorescence in situ Hybridization (LNA flow-FISH): a Method for Bacterial Small RNA Detection

Published on: January 10, 2012

Effect of LNA modifications on small molecule binding to nucleic acids

V Marin1, H F Hansen, T Koch

  • 1Santaris Pharma A/S, Boge alle 3, DK-2970 Horsholm, Denmark.

Journal of Biomolecular Structure & Dynamics
|April 27, 2004
PubMed
Summary

Locked nucleic acid (LNA) alters how DNA-binding molecules interact with DNA and RNA. However, the alkaloid ellipticine maintains strong binding to LNA-containing hybrids, unlike other tested ligands.

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