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Updated: Aug 19, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Herpes simplex virus type 1 remains the principal cause of initial anogenital herpes in Edinburgh, Scotland
K Manavi1, A McMillan, M Ogilvie
1Department of Genitourinary Medicine, Lothian University Teaching Hospitals NHS Trust, Royal Infirmary, Edinburgh, U K. tirbad@yahoo.com
Goal:
The goal of this study was to investigate the trends in the prevalence of anogenital herpes caused by herpes simplex virus (HSV) type-1 and HSV-2 among patients attending a sexually transmitted infections clinic.
Methods:
We conducted a retrospective study of virologically proven first-episode genital herpes diagnosed in the Department of Genitourinary Medicine in Edinburgh between 1989 and 2002.
Results:
First-episode anogenital herpes was associated with HSV-1 in 659 (62%) women and 294 (42%) men (P <0.0002). HSV-1 was recovered more often from women younger than 25 years than from older women (P <0.0005). For both HSV-1 and HSV-2 infections, the median ages of heterosexual men (26.0 and 28.0 years, respectively) were significantly higher than those of women (23.0 and 25.0 years, respectively)(P <0.05). The median age of men who have sex with men with HSV-1 (29.0 years) was significantly higher than that of heterosexual men (26.0 years)(P <0.01).
Conclusion:
HSV-1 remains the most common cause of symptomatic first-episode anogenital herpes, especially among young women in our clinic population.
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