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Substance P expression is elevated in inflamed human periradicular tissue.
Levent I Tuncer1, Tayfun Alaçam, Barbaros Oral
1ltuncer@ttnet.net.tr
Journal of Endodontics
|April 27, 2004
Summary
Substance P, a neuropeptide, was found in immune cells within inflamed human periradicular tissue. This suggests substance P may play a role in modulating inflammation from both nerve and immune cells.
Area of Science:
- Immunology
- Neuroscience
- Oral Biology
Background:
- Substance P is a neuropeptide implicated in neurogenic inflammation.
- Its role in periradicular inflammation requires further investigation.
Purpose of the Study:
- To determine if substance P levels are elevated in inflamed periradicular tissue compared to control tissue.
- To identify the cell types expressing substance P in periradicular inflammation.
Main Methods:
- Immunohistochemical analysis of human periradicular granuloma (n=19) and healthy control pulp tissue (n=2).
- Detection of substance P expression in neutrophils, macrophages, and plasma cells.
Main Results:
- Substance P was detected in neutrophils, macrophages, and plasma cells within both acute and chronic periradicular granulomas.
- Neutrophils expressing substance P were observed even in the absence of acute inflammation symptoms.
- Substance P was also found in control pulp tissue.
Conclusions:
- Substance P is present in immunocompetent cells in inflamed periradicular tissues.
- Substance P may be released from neutrophils and modulate inflammation.
- Both neuronal and immunocompetent cells may contribute to substance P-mediated inflammation in periradicular lesions.