Related Experiment Video
Updated: Aug 24, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
[Chronic lymphocytic leukemia]
1Service d'hématologie clinique, CHU Clemenceau, 14033 Caen. leporrier-m@chu-caen.fr
Abstract:
The last years have yielded important new insights into the biological characteristics of chronic lymphocyte leukemia cells, which have lend to modify the diagnosis and prognosis criteria of the disease. The diagnosis is now based on morphology and immunophenotyping of blood lymphocytes, making the bone marrow examination unnecessary. However, detection of a clonal expansion of B-lymphocytes in the blood is far to be synonymous of leukemia, and even less an argument for starting a treatment. Prognosis classifications based on clinical and blood counts are now refined with genotyping and cytogenetics. These new tools should improved the therapeutic strategies in the next future.
More Related Videos
Related Concept Videos
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

