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Updated: Aug 12, 2026

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
Published on: January 5, 2016
Alpha-synuclein, Parkinson's disease, and Alzheimer's disease
Seonghan Kim1, Ji-Heui Seo, Yoo-Hun Suh
1Department of Pharmacology, College of Medicine, Neuroscience Research Institute, MRC, National Creative Research Initiative Center for Alzheimer's Dementia, Seoul National University, 28 Yongon-dong, Chongno-gu, Seoul 110-799, South Korea.
Abstract:
Alpha synuclein (alpha-SN) is a ubiquitous protein that is especially abundant in the brain and has been postulated to play a central role in the pathogenesis of Parkinson's disease (PD), Alzheimer's disease, and other neurodegenerative disorders. Here, we show that alpha-SN plays dual role of neuroprotection and neurotoxicity depending on its concentration or level of expression. In addition, our study shows that alpha-synuclein is differentially expressed in human peripheral blood mononuclear cells. PD patients expressed more alpha-synuclein than healthy controls. Thus, the alpha-synuclein expression in the peripheral immune system might be one of the primary causes of immune abnormalities in PD patients.
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