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Supported synthesis of ferrocene modified oligonucleotides as new electroactive DNA probes

Aude-Emmanuelle Navarro1, Nicolas Spinelli, Carole Chaix

  • 1Groupe de Chimie Organique et Matériaux Moléculaires, UMR CNRS 6114, Faculté des Sciences de Luminy, case 901, 163 avenue de Luminy, 13288 Marseille Cedex 9, France.

Bioorganic & Medicinal Chemistry Letters
|April 28, 2004
PubMed

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...