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Updated: Aug 24, 2026
Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
New cationic lipids for gene transfer with high efficiency and low toxicity: T-shape cholesterol ester derivatives
Yan Lee1, Heebeom Koo, Yong-beom Lim
1School of Chemistry and Molecular Engineering, Seoul National University, San 56-1, Shillim-dong, Kwanak-ku, Seoul, 151-742, South Korea.
Abstract:
New degradable cationic ester lipids with 'T-shape' configurations were synthesized and tested for gene delivery carrier. Their transfection efficiency and toxicity were compared with commercially available cationic lipids, DOTMA, DOSPA, and DC-Chol. They showed efficient transfection activity and almost no toxicity on mammalian cell lines. Their ester bond degradation was monitored by (1)H NMR.
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