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Updated: Aug 9, 2026
08:47
Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation
Published on: March 5, 2018
CARDINAL roles in apoptosis and NFkappaB activation
Lisa Bouchier-Hayes1, Seamus J Martin
1Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology San Diego, California 92121, USA.
Vitamins and Hormones
|April 28, 2004
Summary
Caspase recruitment domain (CARD) proteins are key players in both apoptosis and immune responses. This review focuses on CARD proteins that activate NF-kappaB signaling pathways in immunity.
Area of Science:
- Immunology
- Molecular Biology
- Cell Signaling
Background:
- Proteins with caspase recruitment domains (CARD) are increasingly identified.
- Some CARD proteins regulate apoptosis via caspase activation.
- Many CARD proteins are involved in immune response signaling.
Purpose of the Study:
- To discuss CARD-containing proteins involved in immune response signaling.
- To highlight the role of CARD proteins in NF-kappaB activation pathways.
Main Methods:
- Literature review of CARD-containing proteins.
- Analysis of their roles in immune signaling pathways.
Main Results:
- Identified numerous CARD proteins.
- Established links between specific CARD proteins and NF-kappaB activation.
- Differentiated roles in apoptosis versus immune signaling.
Conclusions:
- CARD proteins are crucial mediators in innate and adaptive immunity.
- Understanding CARD protein function is vital for immune response research.
- Targeting CARD proteins may offer therapeutic strategies for immune-related diseases.
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