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Related Experiment Videos

TRAIL in the airways.

Noreen M Robertson1, Mary Rosemiller, Rochelle G Lindemeyer

  • 1Department of Biochemistry and Molecular Pharmacology Jefferson Medical College, Thomas Jefferson University Philadelphia, Pennsylvania 19107, USA.

Vitamins and Hormones
|April 28, 2004
PubMed
Summary

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) may influence asthma by acting as a dual-role cytokine. Further research is needed to clarify TRAIL's exact function in airway inflammation.

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Area of Science:

  • Immunology
  • Pulmonology
  • Cell Biology

Background:

  • Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is an immunomodulatory factor.
  • Asthma involves structural changes in airways and inflammation.
  • TRAIL's role in immune responses is complex, acting as both pro- and anti-inflammatory.

Purpose of the Study:

  • To investigate the potential role of TRAIL in the pathogenesis of asthma.
  • To explore TRAIL's expression and function in airway cells relevant to asthma.

Main Methods:

  • Review of in vitro and in vivo studies on TRAIL.
  • Analysis of TRAIL expression in various airway cell types (inflammatory, fibroblasts, epithelial, endothelial, smooth muscle cells).
  • Examination of TRAIL levels in bronchoalveolar lavage fluid from asthmatic patients.

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Main Results:

  • TRAIL exhibits a dual role, acting as a pro- or anti-inflammatory cytokine.
  • TRAIL is expressed by multiple cell types within the asthmatic airway wall.
  • Elevated TRAIL levels are observed in bronchoalveolar lavage fluid of asthma patients.

Conclusions:

  • TRAIL is implicated in airway inflammation associated with asthma.
  • The dual nature of TRAIL's inflammatory modulation requires further investigation.
  • Elucidating TRAIL's precise role in the airways is crucial for understanding asthma pathogenesis.