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Updated: Aug 24, 2026
Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
Published on: October 14, 2016
Left atrium remodeling after acute myocardial infarction (results of the GISSI-3 Echo Substudy)
Bogdan A Popescu1, Franco Macor, Francesco Antonini-Canterin
1Ospedale Civile, Association for Research in Cardiology, Pordenone, Italy.
Insights
This study shows early and late left atrial remodeling occurs after acute myocardial infarction. Left atrial remodeling is linked to left ventricular remodeling in heart attack survivors.
Area of Science:
- Cardiology
- Cardiac Imaging
- Heart Remodeling
Background:
- Left atrial remodeling is a significant concern following myocardial infarction.
- Understanding its timing and determinants is crucial for patient outcomes.
Purpose of the Study:
- To investigate the existence and timing of left atrial remodeling post-myocardial infarction.
- To identify factors influencing left atrial remodeling.
- To explore the relationship between left atrial and left ventricular remodeling.
Main Methods:
- Analysis of a subgroup of 514 patients from the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico Echo Substudy.
- Serial 2-dimensional echocardiograms performed up to 6 months post-acute myocardial infarction.
Main Results:
- Demonstrated the existence of both early and late left atrial remodeling after low-risk acute myocardial infarction.
- Established a relationship between left atrial remodeling and left ventricular remodeling.
Conclusions:
- Left atrial remodeling is a demonstrable phenomenon after acute myocardial infarction.
- The progression of left atrial remodeling is associated with left ventricular changes.
Abstract:
To evaluate the existence, timing, and determinants of post-infarction left atrial remodeling, we studied a subgroup of 514 patients from the Third Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico Echo Substudy who underwent 4 serial 2-dimensional echocardiograms up to 6 months after acute myocardial infarction. This study is the first to demonstrate, in a large series of patients, the existence of early and late left atrial remodeling after low-risk acute myocardial infarction and the relation of left atrial remodeling to left ventricular remodeling.
