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Dendritic cells and autoimmunity

Jagadeesh Bayry1, Marina Thirion, Sandrine Delignat

  • 1INSERM U430 and Université Pierre et Marie Curie, Institut des Cordeliers, 15 rue de l'Ecole de Médecine, Paris 75006, France.

Autoimmunity Reviews
|April 28, 2004
PubMed

Dendritic cells (DC) are professional antigen-presenting cells that are specialized in the uptake of antigens and their transport from peripheral tissues to the lymphoid organs. Because of their capacity to stimulate naive T cells, DC have a central role in the initiation of primary immune responses and are considered promising tools and targets for immunotherapy. Emerging data suggest a role for DC in initiating autoimmune attacks. Direct analysis of DC phenotypes and DC-T-cell interactions in rodent and human autoimmune diseases should shed light on how pathogenesis occurs, and suggest novel avenues of treatment aimed at alleviating deviant DC function.

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