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Updated: Aug 24, 2026

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
Published on: September 10, 2013
Influence of PAMAM dendrimers on human red blood cells
D M Domański1, B Klajnert, M Bryszewska
1Department of General Biophysics, Institute of Biophysics, University of Łódź, 12/16 Banacha Street, Łódź 90-237, Poland.
Abstract:
Polyamidoamine (PAMAM) dendrimers with different concentrations (1 nM-1 mM) (generations 2, 3, and 4) impact on human red blood cell morphology, and membrane integrity is studied. Erythrocyte shape changes from biconcave to echinocytic in dendrimers. Cell aggregation occurs. Polymers cause also concentration- and generation-dependent haemolysis.
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