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Related Concept Videos

Bicarbonate-Carbonic Acid Buffer01:22

Bicarbonate-Carbonic Acid Buffer

The carbonic acid-bicarbonate buffer system is critical for maintaining the body's pH balance. It operates on the equilibrium:

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Establishing In Situ Closed Circuit Perfusion of Lower Abdominal Organs and Hind Limbs in Mice
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Bicarbonate- versus lactate-based CAPD fluids: a biocompatibility study in rabbits.

H T Schambye1, P Flesner, R B Pedersen

  • 1Biomedical Laboratory, Odense University, Denmark.

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|January 1, 1992
PubMed
Summary

This study compared bicarbonate-based and lactate-based continuous ambulatory peritoneal dialysis (CAPD) fluids in rabbits. Results showed no significant biocompatibility difference between the two CAPD fluid types in this animal model.

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Area of Science:

  • Nephrology
  • Biocompatibility Studies
  • Animal Models

Background:

  • In vitro studies suggest bicarbonate-based continuous ambulatory peritoneal dialysis (CAPD) fluids are superior to lactate/acetate-based fluids.
  • In vivo evaluation is necessary to confirm these in vitro findings.

Purpose of the Study:

  • To compare the in vivo biocompatibility of bicarbonate-based and lactate-based CAPD fluids.
  • To assess the safety and efficacy of different CAPD fluid formulations in a rabbit model.

Main Methods:

  • A randomized prospective study involving 41 rabbits undergoing CAPD for four weeks.
  • Comparison of Dianeal (lactate-based) and 87b (bicarbonate-based) CAPD fluids against a control group.
  • Clinical and histopathological assessments, including monitoring for peritonitis and post-mortem examinations.

Main Results:

  • Peritonitis occurred in 8/20 rabbits on Dianeal and 6/21 on 87b, with no controls developing peritonitis.
  • Four rabbits in the Dianeal group required early sacrifice due to severe peritonitis.
  • No significant macroscopic or microscopic differences were found between non-infected groups; key physiological parameters showed no distinctions.

Conclusions:

  • The rabbit CAPD model did not demonstrate a significant difference in biocompatibility between lactate- and bicarbonate-based dialysis fluids.
  • Further research may be needed to elucidate potential subtle differences or optimize CAPD fluid formulations.