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Updated: Aug 24, 2026

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Potent isothiocyanate inhibitors of carbonic anhydrase: synthesis and evaluation
Moussa Khobzaoui1, L M Viranga Tillekeratne, Richard A Hudson
1Department of Chemistry, College of Arts and Sciences, University of Toledo, Toledo, OH 43606, USA.
Abstract:
The reversible hydration of carbon dioxide by carbonic anhydrase (CA) regulates pH and carbon dioxide concentrations in diverse biological systems. Potent irreversible inhibition of CA would facilitate study of the dynamics of CA turnover as well as therapeutic effects due to long-term inhibition of the enzyme. We have synthesized isothiocyanate-containing sulfonamide inhibitors of CA from the corresponding aminosulfonamides. Significant increases in apparent binding of some of the isothiocyanate inhibitors over the amine analogues were consistent with covalent inhibition of the enzyme.
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