Related Experiment Video
Updated: Aug 24, 2026
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[Splenomegaly in sarcoidosis: clinical features and outcome. Analysis of 17 cases]
S Madaule1, D Lauque, L Sailler
1Service de médecine interne, pavillon des médecines, CHU Purpan, place Baylac, 31059 Toulouse cedex, France. madaule.s@chu-toulouse.fr
Purpose:
To describe the clinical features, biological datas and outcome of patients with systemic sarcoidosis and splenomegaly.
Methods:
A retrospective analysis of 17 patients presenting splenomegaly and sarcoidosis with histological proof.
Results:
Splenomegaly was clinically perceptible in 13 patients, with a spleen size that extended 4 cm or more below the costal margin in 11 patients. It was painful in five cases. The more frequent clinical features are constitutional symptom (fever in 9 cases) and hepatomegaly (N =7). Chest X-ray showed bilateral hilar lymphadenopathy in nine patients and no abnormality in five cases. Serum angiotensin converting enzyme levels were elevated in 81% of cases. Thrombopenia (N =5) and hypersplenism (N =5) were also observed. Corticosteroid were given to 88% with a good clinical and biological response including a decrease in the spleen volume. Corticotherapy and splenectomy (performed in two patients to rule out lymphoma) didn't change outcome of disease. Sarcoidosis is often chronical (82%) and extensive.
Conclusion:
Splenomegaly may be present in sarcoidosis. Management is not standardized. Corticosteroid is indicated for symptomatic or massive splenomegaly. Splenomegaly is frequently in chronic and extensive sarcoidosis.
